Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is u...
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| Format: | Online |
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Frontiers Media S.A.
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686650/ |
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pubmed-46866502016-01-05 Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects Cury, Claire Toro, Roberto Cohen, Fanny Fischer, Clara Mhaya, Amel Samper-González, Jorge Hasboun, Dominique Mangin, Jean-François Banaschewski, Tobias Bokde, Arun L. W. Bromberg, Uli Buechel, Christian Cattrell, Anna Conrod, Patricia Flor, Herta Gallinat, Juergen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaitre, Hervé Martinot, Jean-Luc Nees, Frauke Paillère Martinot, Marie-Laure Orfanos, Dimitri P. Paus, Tomas Poustka, Luise Smolka, Michael N. Walter, Henrik Whelan, Robert Frouin, Vincent Schumann, Gunter Glaunès, Joan A. Colliot, Olivier Neuroscience The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ2−test, p < 10−28). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe. Frontiers Media S.A. 2015-12-22 /pmc/articles/PMC4686650/ /pubmed/26733822 http://dx.doi.org/10.3389/fnana.2015.00160 Text en Copyright © 2015 Cury, Toro, Cohen, Fischer, Mhaya, Samper-González, Hasboun, Mangin, Banaschewski, Bokde, Bromberg, Buechel, Cattrell, Conrod, Flor, Gallinat, Garavan, Gowland, Heinz, Ittermann, Lemaitre, Martinot, Nees, Paillère Martinot, Orfanos, Paus, Poustka, Smolka, Walter, Whelan, Frouin, Schumann, Glaunès, Colliot and The IMAGEN Consortium. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cury, Claire Toro, Roberto Cohen, Fanny Fischer, Clara Mhaya, Amel Samper-González, Jorge Hasboun, Dominique Mangin, Jean-François Banaschewski, Tobias Bokde, Arun L. W. Bromberg, Uli Buechel, Christian Cattrell, Anna Conrod, Patricia Flor, Herta Gallinat, Juergen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaitre, Hervé Martinot, Jean-Luc Nees, Frauke Paillère Martinot, Marie-Laure Orfanos, Dimitri P. Paus, Tomas Poustka, Luise Smolka, Michael N. Walter, Henrik Whelan, Robert Frouin, Vincent Schumann, Gunter Glaunès, Joan A. Colliot, Olivier |
| spellingShingle |
Cury, Claire Toro, Roberto Cohen, Fanny Fischer, Clara Mhaya, Amel Samper-González, Jorge Hasboun, Dominique Mangin, Jean-François Banaschewski, Tobias Bokde, Arun L. W. Bromberg, Uli Buechel, Christian Cattrell, Anna Conrod, Patricia Flor, Herta Gallinat, Juergen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaitre, Hervé Martinot, Jean-Luc Nees, Frauke Paillère Martinot, Marie-Laure Orfanos, Dimitri P. Paus, Tomas Poustka, Luise Smolka, Michael N. Walter, Henrik Whelan, Robert Frouin, Vincent Schumann, Gunter Glaunès, Joan A. Colliot, Olivier Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects |
| author_facet |
Cury, Claire Toro, Roberto Cohen, Fanny Fischer, Clara Mhaya, Amel Samper-González, Jorge Hasboun, Dominique Mangin, Jean-François Banaschewski, Tobias Bokde, Arun L. W. Bromberg, Uli Buechel, Christian Cattrell, Anna Conrod, Patricia Flor, Herta Gallinat, Juergen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaitre, Hervé Martinot, Jean-Luc Nees, Frauke Paillère Martinot, Marie-Laure Orfanos, Dimitri P. Paus, Tomas Poustka, Luise Smolka, Michael N. Walter, Henrik Whelan, Robert Frouin, Vincent Schumann, Gunter Glaunès, Joan A. Colliot, Olivier |
| author_sort |
Cury, Claire |
| title |
Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects |
| title_short |
Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects |
| title_full |
Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects |
| title_fullStr |
Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects |
| title_full_unstemmed |
Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects |
| title_sort |
incomplete hippocampal inversion: a comprehensive mri study of over 2000 subjects |
| description |
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ2−test, p < 10−28). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686650/ |
| _version_ |
1613515235442819072 |