Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium Transporter

Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium Transporter

Nucleotide signaling molecules are important intracellular messengers that regulate a wide range of biological functions. The human pathogen Staphylococcus aureus produces the signaling nucleotide cyclic di-AMP (c-di-AMP). This molecule is common among Gram-positive bacteria and in many organisms is...

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Bibliographic Details
Main Authors: Moscoso, Joana A., Schramke, Hannah, Zhang, Yong, Tosi, Tommaso, Dehbi, Amina, Jung, Kirsten, Gründling, Angelika
Format: Online
Language:English
Published: American Society for Microbiology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686210/

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