Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages

Xia et al. report that insulin receptor signaling is required for lymphoid lineage specification in early lymphopoiesis via modulation of Ikaros expression. Disrupted insulin signaling generates more myeloid cells and fewer lymphoid cells, resulting in a skewed myeloid/lymphoid ratio in diabetic mic...

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Main Authors:	Xia, Pengyan, Wang, Shuo, Du, Ying, Huang, Guanling, Satoh, Takashi, Akira, Shizuo, Fan, Zusen
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683997/

id	pubmed-4683997
recordtype	oai_dc
spelling	pubmed-46839972016-06-14 Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages Xia, Pengyan Wang, Shuo Du, Ying Huang, Guanling Satoh, Takashi Akira, Shizuo Fan, Zusen Research Articles Xia et al. report that insulin receptor signaling is required for lymphoid lineage specification in early lymphopoiesis via modulation of Ikaros expression. Disrupted insulin signaling generates more myeloid cells and fewer lymphoid cells, resulting in a skewed myeloid/lymphoid ratio in diabetic mice. The Rockefeller University Press 2015-12-14 /pmc/articles/PMC4683997/ /pubmed/26573296 http://dx.doi.org/10.1084/jem.20150618 Text en © 2015 Xia et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Xia, Pengyan Wang, Shuo Du, Ying Huang, Guanling Satoh, Takashi Akira, Shizuo Fan, Zusen
spellingShingle	Xia, Pengyan Wang, Shuo Du, Ying Huang, Guanling Satoh, Takashi Akira, Shizuo Fan, Zusen Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
author_facet	Xia, Pengyan Wang, Shuo Du, Ying Huang, Guanling Satoh, Takashi Akira, Shizuo Fan, Zusen
author_sort	Xia, Pengyan
title	Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
title_short	Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
title_full	Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
title_fullStr	Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
title_full_unstemmed	Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
title_sort	insulin–insr signaling drives multipotent progenitor differentiation toward lymphoid lineages
description	Xia et al. report that insulin receptor signaling is required for lymphoid lineage specification in early lymphopoiesis via modulation of Ikaros expression. Disrupted insulin signaling generates more myeloid cells and fewer lymphoid cells, resulting in a skewed myeloid/lymphoid ratio in diabetic mice.
publisher	The Rockefeller University Press
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683997/
_version_	1613514412976504832

Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages

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