CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface

CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface

Biogenesis of the TGN-derived transport carriers CARTS requires the ER protein VAP and Golgi lipid transfer proteins, ceramide transfer protein and OSBP. Sac1 lipid phosphatase is recruited to a VAP–OSBP complex formed at an ER subdomain closely apposed to the trans-Golgi/TGN. Association–dissociati...

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Main Authors: Wakana, Yuichi, Kotake, Richika, Oyama, Nanako, Murate, Motohide, Kobayashi, Toshihide, Arasaki, Kohei, Inoue, Hiroki, Tagaya, Mitsuo
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678024/
id pubmed-4678024
recordtype oai_dc
spelling pubmed-46780242016-03-01 CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface Wakana, Yuichi Kotake, Richika Oyama, Nanako Murate, Motohide Kobayashi, Toshihide Arasaki, Kohei Inoue, Hiroki Tagaya, Mitsuo Articles Biogenesis of the TGN-derived transport carriers CARTS requires the ER protein VAP and Golgi lipid transfer proteins, ceramide transfer protein and OSBP. Sac1 lipid phosphatase is recruited to a VAP–OSBP complex formed at an ER subdomain closely apposed to the trans-Golgi/TGN. Association–dissociation dynamics of ER–Golgi contacts are important for CARTS formation. The American Society for Cell Biology 2015-12-15 /pmc/articles/PMC4678024/ /pubmed/26490117 http://dx.doi.org/10.1091/mbc.E15-08-0599 Text en © 2015 Wakana et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Wakana, Yuichi
Kotake, Richika
Oyama, Nanako
Murate, Motohide
Kobayashi, Toshihide
Arasaki, Kohei
Inoue, Hiroki
Tagaya, Mitsuo
spellingShingle Wakana, Yuichi
Kotake, Richika
Oyama, Nanako
Murate, Motohide
Kobayashi, Toshihide
Arasaki, Kohei
Inoue, Hiroki
Tagaya, Mitsuo
CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface
author_facet Wakana, Yuichi
Kotake, Richika
Oyama, Nanako
Murate, Motohide
Kobayashi, Toshihide
Arasaki, Kohei
Inoue, Hiroki
Tagaya, Mitsuo
author_sort Wakana, Yuichi
title CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface
title_short CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface
title_full CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface
title_fullStr CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface
title_full_unstemmed CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface
title_sort carts biogenesis requires vap–lipid transfer protein complexes functioning at the endoplasmic reticulum–golgi interface
description Biogenesis of the TGN-derived transport carriers CARTS requires the ER protein VAP and Golgi lipid transfer proteins, ceramide transfer protein and OSBP. Sac1 lipid phosphatase is recruited to a VAP–OSBP complex formed at an ER subdomain closely apposed to the trans-Golgi/TGN. Association–dissociation dynamics of ER–Golgi contacts are important for CARTS formation.
publisher The American Society for Cell Biology
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678024/
_version_ 1613512568204165120

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