Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins

Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins

GIV is a guanine-nucleotide exchange factor and a bona fide metastasis-related protein. It is found, unexpectedly, that focal adhesions are the major foci for GIV-dependent signaling and that GIV modulates integrin-FAK signaling via activation of G proteins. It is also shown how this phenomenon is a...

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Bibliographic Details
Main Authors: Lopez-Sanchez, Inmaculada, Kalogriopoulos, Nicholas, Lo, I-Chung, Kabir, Firooz, Midde, Krishna K., Wang, Honghui, Ghosh, Pradipta
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666128/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666128/

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