Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis

Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis

The dimeric nature of triosephosphate isomerases (TIMs) is maintained by an extensive surface area interface of more than 1600 Å2. TIMs from Trichomonas vaginalis (TvTIM) are held in their dimeric state by two mechanisms: a ball and socket interaction of residue 45 of one subunit that fits into the...

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Bibliographic Details
Main Authors: Lara-Gonzalez, Samuel, Estrella, Priscilla, Portillo, Carmen, Cruces, María E., Jimenez-Sandoval, Pedro, Fattori, Juliana, Migliorini-Figueira, Ana C., Lopez-Hidalgo, Marisol, Diaz-Quezada, Corina, Lopez-Castillo, Margarita, Trasviña-Arenas, Carlos H., Sanchez-Sandoval, Eugenia, Gómez-Puyou, Armando, Ortega-Lopez, Jaime, Arroyo, Rossana, Benítez-Cardoza, Claudia G., Brieba, Luis G.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664265/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664265/

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