Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis
The inhibition of triosephosphate isomerase (TPI) in glycolysis by the pyruvate kinase (PK) substrate phosphoenolpyruvate (PEP) results in a newly discovered feedback loop that counters oxidative stress in cancer and actively respiring cells. The mechanism underlying this inhibition is illuminated b...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Royal Society
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971408/ |