MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism

MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism

MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. In the current studies, we observed that MUC16 knockdown pancreatic cancer cells exhibit reduced glucose uptake and lactate secretion along with reduced migration and invasion potential, which can be rest...

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Bibliographic Details
Main Authors: Shukla, Surendra K., Gunda, Venugopal, Abrego, Jaime, Haridas, Dhanya, Mishra, Anusha, Souchek, Joshua, Chaika, Nina V., Yu, Fang, Sasson, Aaron R., Lazenby, Audrey J., Batra, Surinder K., Singh, Pankaj K.
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662479/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662479/

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