Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Transmembrane proteins MUC4, EGFR and HER2 are shown to be critical in invasion and metastasis of pancreatic cancer. Besides, we and others have demonstrated de novo expression of MUC4 in ~70-90% of pancreatic cancer patients and its stabilizing effects on HER2 downstream signaling in pancreatic can...

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Bibliographic Details
Main Authors: Seshacharyulu, Parthasarathy, Ponnusamy, Moorthy P., Rachagani, Satyanarayana, Lakshmanan, Imayavaramban, Haridas, Dhanya, Yan, Ying, Ganti, Apar K., Batra, Surinder K.
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467140/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467140/

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