pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity

pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity

The peptide-exchange catalyst, HLA-DM, and its inhibitor, HLA-DO control endosomal generation of peptide/class II major histocompatibility protein (MHC-II) complexes; these complexes traffic to the cell surface for inspection by CD4+ T cells. Some evidence suggests that pH influences DO regulation o...

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Bibliographic Details
Main Authors: Jiang, Wei, Strohman, Michael J., Somasundaram, Sriram, Ayyangar, Sashi, Hou, Tieying, Wang, Nan, Mellins, Elizabeth D.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661524/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661524/

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