G9a Is Essential for Epigenetic Silencing of K+ Channel Genes in Acute-to-Chronic Pain Transition

G9a Is Essential for Epigenetic Silencing of K+ Channel Genes in Acute-to-Chronic Pain Transition

Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little is known about the epigenetic mechanisms involved. Here we show that nerve injury increased H3K9me2 occupanc...

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Bibliographic Details
Main Authors: Laumet, Geoffroy, Garriga, Judit, Chen, Shao-Rui, Zhang, Yuhao, Li, De-Pei, Smith, Trevor M., Dong, Yingchun, Jelinek, Jaroslav, Cesaroni, Matteo, Issa, Jean-Pierre, Pan, Hui-Lin
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661086/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661086/

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