TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

Different molecular subtypes of glioblastoma (GBM) have been recently identified, of which the mesenchymal subtype is associated with worst prognoses. Here, we report that transforming growth factor-β (TGF-β) is able to induce a mesenchymal phenotype in GBM that involves activation of SMAD2 and ZEB1...

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Bibliographic Details
Main Authors: Joseph, J V, Conroy, S, Tomar, T, Eggens-Meijer, E, Bhat, K, Copray, S, Walenkamp, A M E, Boddeke, E, Balasubramanyian, V, Wagemakers, M, den Dunnen, W F A, Kruyt, F A E
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649508/

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