NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

IκB kinase/nuclear factor κB (IKK/NF-κB) signaling exhibits important yet opposing functions in hepatocarcinogenesis. Mice lacking NEMO in liver parenchymal cells (LPC) spontaneously develop steatohepatitis and hepatocellular carcinoma (HCC) suggesting that NF-κB prevents liver disease and cancer. H...

Full description

Bibliographic Details
Main Authors: Kondylis, Vangelis, Polykratis, Apostolos, Ehlken, Hanno, Ochoa-Callejero, Laura, Straub, Beate Katharina, Krishna-Subramanian, Santosh, Van, Trieu-My, Curth, Harald-Morten, Heise, Nicole, Weih, Falk, Klein, Ulf, Schirmacher, Peter, Kelliher, Michelle, Pasparakis, Manolis
Format: Online
Language:English
Published: Cell Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644221/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644221/

Similar Items