Structural basis for phosphatidylinositol-phosphate biosynthesis

Phosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates and proteins to outer cellular membranes. The defining step in phosphatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes that use CDP-diacylglycerol as donor su...

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Bibliographic Details
Main Authors: Clarke, Oliver B., Tomasek, David, Jorge, Carla D., Dufrisne, Meagan Belcher, Kim, Minah, Banerjee, Surajit, Rajashankar, Kanagalaghatta R., Shapiro, Lawrence, Hendrickson, Wayne A., Santos, Helena, Mancia, Filippo
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634129/