S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide

•Hydrogen peroxide is both a toxin and an endogenous signaling molecule.•The use of hydrogen peroxide mouthwash causes ROS mediated damage in cheek cells.•S-glutathionylated proteins are biomarkers for this damage.•S-glutathionylated proteins may be of future value as pharmacodynamic markers....

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Bibliographic Details
Main Authors: Grek, Christina L., Reyes, Leticia, Townsend, Danyelle M., Tew, Kenneth D.
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633976/
Description
Summary:•Hydrogen peroxide is both a toxin and an endogenous signaling molecule.•The use of hydrogen peroxide mouthwash causes ROS mediated damage in cheek cells.•S-glutathionylated proteins are biomarkers for this damage.•S-glutathionylated proteins may be of future value as pharmacodynamic markers.