Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

Here we demonstrate for the first time that targeted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance region 1 (CRM1) by Selective Inhibitor of Nuclear Export (SINE) compounds results in reversal of EMT in snail-transduced primary human mammary epithelial...

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Bibliographic Details
Main Authors: Azmi, Asfar S., Muqbil, Irfana, Wu, Jack, Aboukameel, Amro, Senapedis, William, Baloglu, Erkan, Bollig-Fischer, Aliccia, Dyson, Gregory, Kauffman, Michael, Landesman, Yosef, Shacham, Sharon, Philip, Philip A., Mohammad, Ramzi M.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633607/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633607/

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