Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin

Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin

Survivin, which is highly expressed and promotes cell survival in diffuse malignant peritoneal mesothelioma (DMPM), exclusively relies on exportin 1 (XPO1/CRM1) to be shuttled into the cytoplasm and perform its anti-apoptotic function. Here, we explored the efficacy of Selective Inhibitors of Nuclea...

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Bibliographic Details
Main Authors: De Cesare, Michelandrea, Cominetti, Denis, Doldi, Valentina, Lopergolo, Alessia, Deraco, Marcello, Gandellini, Paolo, Friedlander, Sharon, Landesman, Yosef, Kauffman, Michael G., Shacham, Sharon, Pennati, Marzia, Zaffaroni, Nadia
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537003/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537003/

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