Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF)1

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF)1

In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax lethal toxin. PrAgU2/LF was cytotoxic to five out of nine AML...

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Bibliographic Details
Main Authors: Bekdash, Amira, Darwish, Manal, Timsah, Zahra, Kassab, Elias, Ghanem, Hadi, Najjar, Vicky, Ghosn, Marwan, Nasser, Selim, El-Hajj, Hiba, Bazerbachi, Ali, Liu, Shihui, Leppla, Stephen H., Frankel, Arthur E., Abi-Habib, Ralph J.
Format: Online
Language:English
Published: Neoplasia Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630967/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630967/

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