Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

A SARS-CoV lacking the full-length E gene (SARS-CoV-∆E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the partial duplication of the membrane gene or in the insertion of a new sequence in...

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Bibliographic Details
Main Authors: Jimenez-Guardeño, Jose M., Regla-Nava, Jose A., Nieto-Torres, Jose L., DeDiego, Marta L., Castaño-Rodriguez, Carlos, Fernandez-Delgado, Raul, Perlman, Stanley, Enjuanes, Luis
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626112/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626112/

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