The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major determinant of virulence. Elimination of SARS-CoV E prot...

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Bibliographic Details
Main Authors: Jimenez-Guardeño, Jose M., Nieto-Torres, Jose L., DeDiego, Marta L., Regla-Nava, Jose A., Fernandez-Delgado, Raul, Castaño-Rodriguez, Carlos, Enjuanes, Luis
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133396/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133396/

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