Intratumor Heterogeneity of K-Ras and p53 Mutations among Human Colorectal Adenomas Containing Early Cancer

The molecular pathways and the timing of genetic events during human colorectal carcinogenesis are still not fully understood. We have addressed the intratumor heterogeneity of the mutational status of the k‐ras oncogene and of the p53 oncosuppressor gene during the adenoma–carcinoma sequence by inv...

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Bibliographic Details
Main Authors: Giaretti, Walter, Macciocu, Barbara, Geido, Elio, Hermsen, Mario, Postma, Cindy, Baak, Jan, Williams, Richard, Meijer, Gerrit
Format: Online
Language:English
Published: IOS Press 2000
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615987/