Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer

There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation ach...

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Main Authors:	Conde-Muíño, Raquel, Cuadros, Marta, Zambudio, Natalia, Segura-Jiménez, Inmaculada, Cano, Carlos, Palma, Pablo
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609421/

id	pubmed-4609421
recordtype	oai_dc
spelling	pubmed-46094212015-10-26 Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo Review Article There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting which patients will respond to neoadjuvant treatment. Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation. The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile's ability to predict response to neoadjuvant treatment in rectal cancer. Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice. Hindawi Publishing Corporation 2015 2015-10-04 /pmc/articles/PMC4609421/ /pubmed/26504848 http://dx.doi.org/10.1155/2015/921435 Text en Copyright © 2015 Raquel Conde-Muíño et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo
spellingShingle	Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
author_facet	Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo
author_sort	Conde-Muíño, Raquel
title	Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
title_short	Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
title_full	Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
title_fullStr	Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
title_full_unstemmed	Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
title_sort	predictive biomarkers to chemoradiation in locally advanced rectal cancer
description	There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting which patients will respond to neoadjuvant treatment. Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation. The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile's ability to predict response to neoadjuvant treatment in rectal cancer. Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609421/
_version_	1613489495312695296

Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer

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