APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

APPL1 vesicles represent a distinct population of Rab5-positive early endosomes that undergoes fusion and fission and sorts and exchanges cargo with EEA1 endosomes, suggesting a new organization of the endocytic pathway.

Bibliographic Details
Main Authors: Kalaidzidis, Inna, Miaczynska, Marta, Brewińska-Olchowik, Marta, Hupalowska, Anna, Ferguson, Charles, Parton, Robert G., Kalaidzidis, Yannis, Zerial, Marino
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602042/