Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

Glioblastoma multiforme (GBM) often features a combination of tumour suppressor gene inactivation and multiple oncogene overactivation. The Axl receptor tyrosine kinase is found overexpressed in GBM and thought to contribute to invasiveness, chemoresistance and poor survival. Here, we have evaluated...

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Main Authors:	Vouri, Mikaella, An, Qian, Birt, Matthew, Pilkington, Geoffrey J., Hafizi, Sassan
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599264/

id	pubmed-4599264
recordtype	oai_dc
spelling	pubmed-45992642015-10-26 Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells Vouri, Mikaella An, Qian Birt, Matthew Pilkington, Geoffrey J. Hafizi, Sassan Research Paper Glioblastoma multiforme (GBM) often features a combination of tumour suppressor gene inactivation and multiple oncogene overactivation. The Axl receptor tyrosine kinase is found overexpressed in GBM and thought to contribute to invasiveness, chemoresistance and poor survival. Here, we have evaluated the effect of BGB324, a clinical candidate Axl-specific small molecule inhibitor, on the invasive behaviour of human GBM cells in vitro, as an indicator of its potential in GBM therapy and also to elucidate the role of Axl in GBM pathogenesis. Impact Journals LLC 2015-04-29 /pmc/articles/PMC4599264/ /pubmed/25980499 Text en Copyright: © 2015 Vouri et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Vouri, Mikaella An, Qian Birt, Matthew Pilkington, Geoffrey J. Hafizi, Sassan
spellingShingle	Vouri, Mikaella An, Qian Birt, Matthew Pilkington, Geoffrey J. Hafizi, Sassan Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
author_facet	Vouri, Mikaella An, Qian Birt, Matthew Pilkington, Geoffrey J. Hafizi, Sassan
author_sort	Vouri, Mikaella
title	Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
title_short	Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
title_full	Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
title_fullStr	Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
title_full_unstemmed	Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
title_sort	small molecule inhibition of axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
description	Glioblastoma multiforme (GBM) often features a combination of tumour suppressor gene inactivation and multiple oncogene overactivation. The Axl receptor tyrosine kinase is found overexpressed in GBM and thought to contribute to invasiveness, chemoresistance and poor survival. Here, we have evaluated the effect of BGB324, a clinical candidate Axl-specific small molecule inhibitor, on the invasive behaviour of human GBM cells in vitro, as an indicator of its potential in GBM therapy and also to elucidate the role of Axl in GBM pathogenesis.
publisher	Impact Journals LLC
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599264/
_version_	1613485685589671936

Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

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