Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

Sézary syndrome (SS) is an aggressive leukaemia of mature T cells with poor prognosis and limited options for targeted therapies. The comprehensive genetic alterations underlying the pathogenesis of SS are unknown. Here we integrate whole-genome sequencing (n=6), whole-exome sequencing (n=66) and ar...

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Bibliographic Details
Main Authors: Kiel, Mark J., Sahasrabuddhe, Anagh A., Rolland, Delphine C. M., Velusamy, Thirunavukkarasu, Chung, Fuzon, Schaller, Matthew, Bailey, Nathanael G., Betz, Bryan L., Miranda, Roberto N., Porcu, Pierluigi, Byrd, John C., Jeffrey Medeiros, L., Kunkel, Steven L., Bahler, David W., Lim, Megan S., Elenitoba-Johnson, Kojo S. J.
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598843/

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