UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration
Neurodegenerative diseases are a leading cause of disability and early death. A common feature of these conditions is disruption of protein homeostasis. Ubiquitin-like modifier activating enzyme 1 (UBA1), the E1 ubiquitin-activating enzyme, sits at the apex of the ubiquitin cascade and represents an...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science Ltd
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596250/ |