Ubiquitin binding by the p62 UBA domain
Over 30 different mutations in p62 UBA have been identified in patients with Paget's disease of bone (PDB). The mechanisms which underlie PDB are poorly understood, although impaired ubiquitin binding has been identified as a mechanism in the onset of disease. However, the decrease in affinity...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2013
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| Online Access: | http://eprints.nottingham.ac.uk/14519/ http://eprints.nottingham.ac.uk/14519/1/594862.pdf |