Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-321,2,3

Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-321,2,3

Type 10A phosphodiesterase (PDE10A) is highly expressed in the striatum, in striatonigral and striatopallidal medium-sized spiny neurons (MSNs), which express D1 and D2 dopamine receptors, respectively. PDE10A inhibitors have pharmacological and behavioral effects suggesting an antipsychotic profile...

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Bibliographic Details
Main Authors: Polito, Marina, Guiot, Elvire, Gangarossa, Giuseppe, Longueville, Sophie, Doulazmi, Mohamed, Valjent, Emmanuel, Hervé, Denis, Girault, Jean-Antoine, Paupardin-Tritsch, Danièle, Castro, Liliana R. V., Vincent, Pierre
Format: Online
Language:English
Published: Society for Neuroscience 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596023/

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