Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation

Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation

Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A, a PDE isoform with 40–100-...

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Bibliographic Details
Main Authors: Vang, Amanda G., Basole, Chaitali, Dong, Hongli, Nguyen, Rebecca K., Housley, William, Guernsey, Linda, Adami, Alexander J., Thrall, Roger S., Clark, Robert B., Epstein, Paul M., Brocke, Stefan
Format: Online
Language:English
Published: Frontiers Media S.A. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993990/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993990/

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