ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS
Peroxisomes are highly metabolic, autonomously replicating organelles that generate ROS as a by product of fatty acid β-oxidation. Consequently, cells must maintain peroxisome homeostasis, or risk pathologies associated with too few peroxisomes, such as peroxisome biogenesis disorders, or too many p...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
2015
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589490/ |