In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in inflammation, carcinogenesis and defense against infection. The cytotoxic activity of natural killer (NK) cells in TYK2-deficient (Tyk2−/−) mice is severely reduced, although the underlying mechanisms are largely unknown....

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Bibliographic Details
Main Authors: Prchal-Murphy, Michaela, Witalisz-Siepracka, Agnieszka, Bednarik, Karoline T, Putz, Eva Maria, Gotthardt, Dagmar, Meissl, Katrin, Sexl, Veronika, Müller, Mathias, Strobl, Birgit
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589058/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589058/

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