TYK2 Promoter Variant and Diabetes Mellitus in the Japanese

•TYK2 promoter variant with multiple polymorphisms was identified in the Japanese.•TYK2 promoter variant is associated with an increased risk of both type 1 and type 2 diabetes.•TYK2 promoter variant serves a good candidate as a virus-induced diabetes susceptibility gene in humans.

Bibliographic Details
Main Authors: Nagafuchi, Seiho, Kamada-Hibio, Yumi, Hirakawa, Kanako, Tsutsu, Nobutaka, Minami, Masae, Okada, Akira, Kai, Katsuya, Teshima, Miho, Moroishi, Arisa, Murakami, Yoshikazu, Umeno, Yoshikazu, Yokogawa, Yasushi, Kogawa, Kazuhiko, Izumi, Kenichi, Anzai, Keizo, Iwakiri, Ryuichi, Hamaguchi, Kazuyuki, Sasaki, Nobuhiro, Nohara, Sakae, Yoshida, Eiko, Harada, Mine, Akashi, Koichi, Yanase, Toshihiko, Ono, Junko, Okeda, Toshimitsu, Fujimoto, Ryoji, Ihara, Kenji, Hara, Toshiro, Kikuchi, Yohei, Iwase, Masanori, Kitazono, Takanari, Kojima, Fumiko, Kono, Suminori, Kurisaki, Hironori, Kondo, Shiori, Katsuta, Hitoshi
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534683/