Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation

Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated a...

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Main Authors:	Lee, Na-Rae, Kim, Hye-In, Choi, Myung-Soo, Yi, Chae-Min, Inn, Kyung-Soo
Format:	Online
Language:	English
Published:	Korean Society for Molecular and Cellular Biology 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588718/

id	pubmed-4588718
recordtype	oai_dc
spelling	pubmed-45887182015-10-13 Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation Lee, Na-Rae Kim, Hye-In Choi, Myung-Soo Yi, Chae-Min Inn, Kyung-Soo Article Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated activation of NF-κB and interferon production. TRIM25 is required for the full activation of NF-κB at the downstream of MAVS, while it is not involved in IRF3 nuclear translocation. Mechanical studies showed that TRIM25 is involved in TRAF6-mediated NF-κB activation. These collectively indicate that TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-κB. Korean Society for Molecular and Cellular Biology 2015-09-30 2015-08-21 /pmc/articles/PMC4588718/ /pubmed/26299329 http://dx.doi.org/10.14348/molcells.2015.0047 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lee, Na-Rae Kim, Hye-In Choi, Myung-Soo Yi, Chae-Min Inn, Kyung-Soo
spellingShingle	Lee, Na-Rae Kim, Hye-In Choi, Myung-Soo Yi, Chae-Min Inn, Kyung-Soo Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
author_facet	Lee, Na-Rae Kim, Hye-In Choi, Myung-Soo Yi, Chae-Min Inn, Kyung-Soo
author_sort	Lee, Na-Rae
title	Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
title_short	Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
title_full	Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
title_fullStr	Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
title_full_unstemmed	Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
title_sort	regulation of mda5-mavs antiviral signaling axis by trim25 through traf6-mediated nf-κb activation
description	Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated activation of NF-κB and interferon production. TRIM25 is required for the full activation of NF-κB at the downstream of MAVS, while it is not involved in IRF3 nuclear translocation. Mechanical studies showed that TRIM25 is involved in TRAF6-mediated NF-κB activation. These collectively indicate that TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-κB.
publisher	Korean Society for Molecular and Cellular Biology
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588718/
_version_	1613481982755340288

Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation

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