Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner
Tenofovir (TFV) is used in combination with other antiretroviral drugs for human immunodeficiency virus (HIV) treatment and prevention. TFV requires two phosphorylation steps to become pharmacologically active; however, the kinases that activate TFV in cells and tissues susceptible to HIV infection...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588390/ |