A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

This Phase 1, randomized, two-site (United States), double-blind, placebo-controlled study enrolled 18 sexually abstinent men and women. All received a single 300-mg dose of oral tenofovir disoproxil fumarate (TDF) and were then randomized 2∶1 to receive single and then seven daily rectal exposures...

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Bibliographic Details
Main Authors: Yang, Kuo-Hsiung, Hendrix, Craig, Bumpus, Namandje, Elliott, Julie, Tanner, Karen, Mauck, Christine, Cranston, Ross, McGowan, Ian, Richardson-Harman, Nicola, Anton, Peter A., Kashuba, Angela D. M.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211672/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211672/

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