Androgen receptor modulates Foxp3 expression in CD4+CD25+Foxp3+ regulatory T-cells

Androgen receptor modulates Foxp3 expression in CD4+CD25+Foxp3+ regulatory T-cells

CD4+CD25+Foxp3+ Treg cells are crucial for the maintenance of immunological homeostasis. Androgens significantly induce Foxp3 expression in humans and regulate the differentiation of Treg cells. A functional androgen receptor–binding site is identified within the Foxp3 locus leading to epigenetic ch...

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Bibliographic Details
Main Authors: Walecki, Magdalena, Eisel, Florian, Klug, Jörg, Baal, Nelli, Paradowska-Dogan, Agnieszka, Wahle, Eva, Hackstein, Holger, Meinhardt, Andreas, Fijak, Monika
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571343/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571343/

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