A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction
An alternative splice in TOCA-1 targets it to tight junctions. KO of TOCA-1 results in increased flux and decreased tight junction membrane dynamics. Ultrastructural analysis shows actin accumulation at the adherens junction. Identification of the ZO-1/TOCA-1 complex provides insights into tight jun...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571337/ |