Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

BRCA1 and 53BP1 antagonistically regulate homology-directed repair (HDR) and non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSB). The histone deacetylase (HDAC) inhibitor trichostatin A directly inhibits the retention of 53BP1 at DSB sites by acetylating histone H4 (H4ac), which inte...

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Bibliographic Details
Main Authors: Fukuda, Takayo, Wu, Wenwen, Okada, Maiko, Maeda, Ichiro, Kojima, Yasuyuki, Hayami, Ryosuke, Miyoshi, Yasuo, Tsugawa, Ko-ichiro, Ohta, Tomohiko
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556395/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556395/

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