Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels

Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels

Replacement of a single proline with threonine gives rise to an altered conformation of the Drosophila CNG channel selectivity filter that leads to weak Ca2+ block of monovalent ion current.

Bibliographic Details
Main Authors: Lam, Yee Ling, Zeng, Weizhong, Derebe, Mehabaw Getahun, Jiang, Youxing
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555469/
id pubmed-4555469
recordtype oai_dc
spelling pubmed-45554692016-03-01 Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels Lam, Yee Ling Zeng, Weizhong Derebe, Mehabaw Getahun Jiang, Youxing Communication Replacement of a single proline with threonine gives rise to an altered conformation of the Drosophila CNG channel selectivity filter that leads to weak Ca2+ block of monovalent ion current. The Rockefeller University Press 2015-09 /pmc/articles/PMC4555469/ /pubmed/26283200 http://dx.doi.org/10.1085/jgp.201511431 Text en © 2015 Lam et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Lam, Yee Ling
Zeng, Weizhong
Derebe, Mehabaw Getahun
Jiang, Youxing
spellingShingle Lam, Yee Ling
Zeng, Weizhong
Derebe, Mehabaw Getahun
Jiang, Youxing
Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels
author_facet Lam, Yee Ling
Zeng, Weizhong
Derebe, Mehabaw Getahun
Jiang, Youxing
author_sort Lam, Yee Ling
title Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels
title_short Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels
title_full Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels
title_fullStr Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels
title_full_unstemmed Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide–gated channels
title_sort structural implications of weak ca2+ block in drosophila cyclic nucleotide–gated channels
description Replacement of a single proline with threonine gives rise to an altered conformation of the Drosophila CNG channel selectivity filter that leads to weak Ca2+ block of monovalent ion current.
publisher The Rockefeller University Press
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555469/
_version_ 1613471217677762560

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