TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

TRIM5α is an antiviral, cytoplasmic, E3 ubiquitin (Ub) ligase that assembles on incoming retroviral capsids and induces their premature dissociation. It inhibits reverse transcription of the viral genome and can also synthesize unanchored polyubiquitin (polyUb) chains to stimulate innate immune resp...

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Bibliographic Details
Main Authors: Fletcher, Adam J, Christensen, Devin E, Nelson, Chad, Tan, Choon Ping, Schaller, Torsten, Lehner, Paul J, Sundquist, Wesley I, Towers, Greg J
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551353/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551353/

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