Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

Mechanisms of muscle atrophy are complex and their understanding might help finding therapeutic solutions for pathologies such as amyotrophic lateral sclerosis (ALS). We meta-analyzed transcriptomic experiments of muscles of ALS patients and mouse models, uncovering a p53 deregulation as common deno...

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Bibliographic Details
Main Authors: von Grabowiecki, Yannick, Abreu, Paula, Blanchard, Orphee, Palamiuc, Lavinia, Benosman, Samir, Mériaux, Sophie, Devignot, Véronique, Gross, Isabelle, Mellitzer, Georg, Gonzalez de Aguilar, José L, Gaiddon, Christian
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786414/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786414/

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