Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain

Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain

•Many pathogens bind the Fc region of host immunoglobulin to evade immunity.•We examined a Plasmodium falciparum IgM binding PfEMP1 domain TM284var1 DBL4ζ.•We identified the minimal IgM binding region comprising subdomain 2 and flanking regions.•Specific charged amino acids were mutated but did not...

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Main Authors: Semblat, Jean-Philippe, Ghumra, Ashfaq, Czajkowsky, Daniel M., Wallis, Russell, Mitchell, Daniel A., Raza, Ahmed, Rowe, J.Alexandra
Format: Online
Language:English
Published: Elsevier/North-Holland Biomedical Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539346/
id pubmed-4539346
recordtype oai_dc
spelling pubmed-45393462015-08-26 Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain Semblat, Jean-Philippe Ghumra, Ashfaq Czajkowsky, Daniel M. Wallis, Russell Mitchell, Daniel A. Raza, Ahmed Rowe, J.Alexandra Article •Many pathogens bind the Fc region of host immunoglobulin to evade immunity.•We examined a Plasmodium falciparum IgM binding PfEMP1 domain TM284var1 DBL4ζ.•We identified the minimal IgM binding region comprising subdomain 2 and flanking regions.•Specific charged amino acids were mutated but did not markedly affect IgM binding.•Existing models of PfEMP1-IgM interaction need to be revised. Elsevier/North-Holland Biomedical Press 2015-05 /pmc/articles/PMC4539346/ /pubmed/26094597 http://dx.doi.org/10.1016/j.molbiopara.2015.06.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Semblat, Jean-Philippe
Ghumra, Ashfaq
Czajkowsky, Daniel M.
Wallis, Russell
Mitchell, Daniel A.
Raza, Ahmed
Rowe, J.Alexandra
spellingShingle Semblat, Jean-Philippe
Ghumra, Ashfaq
Czajkowsky, Daniel M.
Wallis, Russell
Mitchell, Daniel A.
Raza, Ahmed
Rowe, J.Alexandra
Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain
author_facet Semblat, Jean-Philippe
Ghumra, Ashfaq
Czajkowsky, Daniel M.
Wallis, Russell
Mitchell, Daniel A.
Raza, Ahmed
Rowe, J.Alexandra
author_sort Semblat, Jean-Philippe
title Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain
title_short Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain
title_full Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain
title_fullStr Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain
title_full_unstemmed Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain
title_sort identification of the minimal binding region of a plasmodium falciparum igm binding pfemp1 domain
description •Many pathogens bind the Fc region of host immunoglobulin to evade immunity.•We examined a Plasmodium falciparum IgM binding PfEMP1 domain TM284var1 DBL4ζ.•We identified the minimal IgM binding region comprising subdomain 2 and flanking regions.•Specific charged amino acids were mutated but did not markedly affect IgM binding.•Existing models of PfEMP1-IgM interaction need to be revised.
publisher Elsevier/North-Holland Biomedical Press
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539346/
_version_ 1613260549585371136

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