Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain

Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain

•Many pathogens bind the Fc region of host immunoglobulin to evade immunity.•We examined a Plasmodium falciparum IgM binding PfEMP1 domain TM284var1 DBL4ζ.•We identified the minimal IgM binding region comprising subdomain 2 and flanking regions.•Specific charged amino acids were mutated but did not...

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Bibliographic Details
Main Authors: Semblat, Jean-Philippe, Ghumra, Ashfaq, Czajkowsky, Daniel M., Wallis, Russell, Mitchell, Daniel A., Raza, Ahmed, Rowe, J.Alexandra
Format: Online
Language:English
Published: Elsevier/North-Holland Biomedical Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539346/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539346/

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