The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis

We identified a dominant missense mutation in the SCN transcription factor Zfhx3, termed short circuit (Zfhx3Sci), which accelerates circadian locomotor rhythms in mice. ZFHX3 regulates transcription via direct interaction with predicted AT motifs in target genes. The mutant protein has a decreased...

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Bibliographic Details
Main Authors: Parsons, Michael J., Brancaccio, Marco, Sethi, Siddharth, Maywood, Elizabeth S., Satija, Rahul, Edwards, Jessica K., Jagannath, Aarti, Couch, Yvonne, Finelli, Mattéa J., Smyllie, Nicola J., Esapa, Christopher, Butler, Rachel, Barnard, Alun R., Chesham, Johanna E., Saito, Shoko, Joynson, Greg, Wells, Sara, Foster, Russell G., Oliver, Peter L., Simon, Michelle M., Mallon, Ann-Marie, Hastings, Michael H., Nolan, Patrick M.
Format: Online
Language:English
Published: Cell Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537516/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537516/

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