Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B

Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B

To evaluate cell mediated immunopathogenic mechanisms in chronic hepatitis B virus (HBV) infection, we investigated the changes of T4/T8 ratios from the peripheral blood, the percentages of IL-2 receptor expression after stimulation of mitogens (Con A, PHA) and a specific antigen (Hepatitis type B s...

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Main Authors: Ahn, Deuk Soo, Jang, Hyun Cheol, Ahn, Joong Ki, Yim, Chang Yeol, Kim, Dae Ghon
Format: Online
Language:English
Published: Korean Association of Internal Medicine 1989
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534971/
id pubmed-4534971
recordtype oai_dc
spelling pubmed-45349712015-10-02 Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B Ahn, Deuk Soo Jang, Hyun Cheol Ahn, Joong Ki Yim, Chang Yeol Kim, Dae Ghon Original Article To evaluate cell mediated immunopathogenic mechanisms in chronic hepatitis B virus (HBV) infection, we investigated the changes of T4/T8 ratios from the peripheral blood, the percentages of IL-2 receptor expression after stimulation of mitogens (Con A, PHA) and a specific antigen (Hepatitis type B surface antigen, HBs), and the proliferative response mediated by IL-2 receptors after rlL-2 stimulation on mixed mononuclear cell. These experiments were performed comparatively in 5 groups which consisted of serologically negative normal subjects, chronic HBV carriers, patients with chronic active hepatitis (CAH) type B, patients with acute hepatitis (AH) type B, and the antibody positive healthy subjects. Korean Association of Internal Medicine 1989-01 /pmc/articles/PMC4534971/ /pubmed/2487403 http://dx.doi.org/10.3904/kjim.1989.4.1.34 Text en Copyright © 1989 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ahn, Deuk Soo
Jang, Hyun Cheol
Ahn, Joong Ki
Yim, Chang Yeol
Kim, Dae Ghon
spellingShingle Ahn, Deuk Soo
Jang, Hyun Cheol
Ahn, Joong Ki
Yim, Chang Yeol
Kim, Dae Ghon
Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B
author_facet Ahn, Deuk Soo
Jang, Hyun Cheol
Ahn, Joong Ki
Yim, Chang Yeol
Kim, Dae Ghon
author_sort Ahn, Deuk Soo
title Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B
title_short Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B
title_full Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B
title_fullStr Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B
title_full_unstemmed Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B
title_sort impaired lnterleukin-2 receptor expression on lymphocytes from patients with chronic active hepatitis type b
description To evaluate cell mediated immunopathogenic mechanisms in chronic hepatitis B virus (HBV) infection, we investigated the changes of T4/T8 ratios from the peripheral blood, the percentages of IL-2 receptor expression after stimulation of mitogens (Con A, PHA) and a specific antigen (Hepatitis type B surface antigen, HBs), and the proliferative response mediated by IL-2 receptors after rlL-2 stimulation on mixed mononuclear cell. These experiments were performed comparatively in 5 groups which consisted of serologically negative normal subjects, chronic HBV carriers, patients with chronic active hepatitis (CAH) type B, patients with acute hepatitis (AH) type B, and the antibody positive healthy subjects.
publisher Korean Association of Internal Medicine
publishDate 1989
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534971/
_version_ 1613259130193051648

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