Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B

Impaired lnterleukin-2 Receptor Expression on Lymphocytes from Patients with Chronic Active Hepatitis Type B

To evaluate cell mediated immunopathogenic mechanisms in chronic hepatitis B virus (HBV) infection, we investigated the changes of T4/T8 ratios from the peripheral blood, the percentages of IL-2 receptor expression after stimulation of mitogens (Con A, PHA) and a specific antigen (Hepatitis type B s...

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Bibliographic Details
Main Authors: Ahn, Deuk Soo, Jang, Hyun Cheol, Ahn, Joong Ki, Yim, Chang Yeol, Kim, Dae Ghon
Format: Online
Language:English
Published: Korean Association of Internal Medicine 1989
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534971/
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Summary:To evaluate cell mediated immunopathogenic mechanisms in chronic hepatitis B virus (HBV) infection, we investigated the changes of T4/T8 ratios from the peripheral blood, the percentages of IL-2 receptor expression after stimulation of mitogens (Con A, PHA) and a specific antigen (Hepatitis type B surface antigen, HBs), and the proliferative response mediated by IL-2 receptors after rlL-2 stimulation on mixed mononuclear cell. These experiments were performed comparatively in 5 groups which consisted of serologically negative normal subjects, chronic HBV carriers, patients with chronic active hepatitis (CAH) type B, patients with acute hepatitis (AH) type B, and the antibody positive healthy subjects.

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