Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

Bibliographic Details
Main Authors:	Ling, I-Fang, Golde, Todd E., Galasko, Douglas R., Koo, Edward H.
Format:	Online
Language:	English
Published:	BioMed Central 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523931/

Similar Items

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
by: Lessard, Christian B., et al.
Published: (2015)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
by: Jung, Joo In, et al.
Published: (2014)

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator
by: Jung, Joo In, et al.
Published: (2015)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
by: Uemura, Kengo, et al.
Published: (2010)

γ-secretase inhibitors and modulators induce distinct conformational changes in the active sites of γ-secretase and signal peptide peptidase
by: Gertsik, Natalya, et al.
Published: (2015)

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
by: Gerakis, Yannis, et al.
Published: (2016)

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers
by: Soares, Holly D., et al.
Published: (2016)

Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells
by: Jumpertz, Thorsten, et al.
Published: (2012)

γ-Secretase Modulators: Can We Combine Potency with Safety?
by: Gijsen, Harrie J. M., et al.
Published: (2012)

APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment
by: Sjödin, Simon, et al.
Published: (2015)

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
by: Toyn, Jeremy H., et al.
Published: (2014)

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology
by: Liu, Xiaosong, et al.
Published: (2013)

A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP
by: Weissmiller, April M., et al.
Published: (2015)

Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems
by: Galasko, Douglas, et al.
Published: (2013)

γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ42/Aβ40 ratio
by: Hedskog, Louise, et al.
Published: (2011)

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity
by: Jung, Joo In, et al.
Published: (2014)

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species
by: Wagner, Steven L., et al.
Published: (2014)

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor
by: Ortega, Fernando, et al.
Published: (2013)

Structural basis of human γ-secretase assembly
by: Sun, Linfeng, et al.
Published: (2015)

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
by: Xu, Ting-Hai, et al.
Published: (2016)

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates
by: Nyborg, Andrew C, et al.
Published: (2006)

APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation
by: Mertens, Jerome, et al.
Published: (2013)

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
by: Toyn, Jeremy H., et al.
Published: (2016)

Right sizing funding for Alzheimer's disease
by: Golde, Todd E, et al.
Published: (2011)

Recent Alzheimer's disease research highlights
by: Galasko, Douglas, et al.
Published: (2012)

Progress in Alzheimer's disease research circa 2013: Is the glass half empty or half full?
by: Galasko, Douglas, et al.
Published: (2013)

Structure-function relationship of γ-secretase
by: Tomita, Taisuke
Published: (2012)

The dynamic conformational landscape of γ-secretase
by: Elad, Nadav, et al.
Published: (2015)

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease
by: Tate, Barbara, et al.
Published: (2012)

The composition of the γ-secretase complex defines its Aβ product profile
by: Acx, Hermien, et al.
Published: (2013)

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease
by: MacLeod, Ruth, et al.
Published: (2015)

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors
by: Ran, Yong, et al.
Published: (2015)

The biological function of β-secretase
by: Haass, Christian
Published: (2013)

Modulation of γ-Secretase Activity by Multiple Enzyme-Substrate Interactions: Implications in Pathogenesis of Alzheimer's Disease
by: Svedružić, Željko M., et al.
Published: (2012)

Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer’s Disease
by: Bulic, Bruno, et al.
Published: (2011)

Correction: Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease
by: Svedružić, Željko M., et al.
Published: (2013)

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
by: Rogers, Kathryn, et al.
Published: (2012)

Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease
by: Svedružić, Željko M., et al.
Published: (2013)

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease
by: Blain, Jean-François, et al.
Published: (2016)

Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
by: Brendel, M, et al.
Published: (2015)