Structural basis of human γ-secretase assembly

Structural basis of human γ-secretase assembly

Unlike other single-component intramembrane proteases such as rhomboid and S2P, γ-secretase contains four components: presenilin, Pen-2, Aph-1, and nicastrin. Previous electron cryomicroscopy (cryo-EM) analysis of human γ-secretase in amphipols revealed its overall architecture and 19 distinct trans...

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Bibliographic Details
Main Authors: Sun, Linfeng, Zhao, Lingyun, Yang, Guanghui, Yan, Chuangye, Zhou, Rui, Zhou, Xiaoyuan, Xie, Tian, Zhao, Yanyu, Wu, Shenjie, Li, Xueming, Shi, Yigong
Format: Online
Language:English
Published: National Academy of Sciences 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434707/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434707/

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