Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex

DNA methylation at selective cytosine residues (5mC) and their removal by TET-mediated DNA demethylation are critical for setting up pluripotent states in early embryonic development1–2. TET enzymes successively convert 5mC to 5hmC, 5fC, and 5caC, the latter two of which are subject to removal by th...

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Bibliographic Details
Main Authors: Wang, Lanfeng, Zhou, Yu, Xu, Liang, Xiao, Rui, Lu, Xingyu, Chen, Liang, Chong, Jenny, Li, Hairi, He, Chuan, Fu, Xiang-Dong, Wang, Dong
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521995/