Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution

Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution

RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity. Our previous ‘synthetic nucleic acid substitution’ strategy has been successfully applied in dissecting the function of nucl...

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Bibliographic Details
Main Authors: Hwang, Candy S., Xu, Liang, Wang, Wei, Ulrich, Sébastien, Zhang, Lu, Chong, Jenny, Shin, Ji Hyun, Huang, Xuhui, Kool, Eric T., McKenna, Charles E., Wang, Dong
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857003/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857003/

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